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. 2011 Dec 14;37(5):1245–1256. doi: 10.1038/npp.2011.312

Figure 3.

Figure 3

Adenosine A2A agonist CGS 21680 does not alter cocaine-induced locomotor behavior. (a) No significant differences were observed in total cocaine-induced locomotor activity over the 2-h test period of animals between receiving a pretreatment with 0.0, 2.5 and 5.0 ng per side CGS 21680 before cocaine (15 mg/kg, intraperitoneally). (b) Time course of locomotor activity illustrating the last 30 min of the habituation period (−30 to 0 min), followed by the effects of 15 mg/kg cocaine (intraperitoneally) with and without a pretreatment of intra-nucleus accumbens (NAc) CGS 21680. Note the significant differences in the time course of the cocaine-induced locomotor activity at 5 ng per side CGS 21680 (p<0.01 Bonferroni's post-test). Number of animals per treatment group: 0.0 CGS/15 mg/kg cocaine=4, 2.5 ng CGS/15 mg/kg cocaine=5, and 5.0 ng CGS/15 mg/kg cocaine=4.