Table 1. Concentrations of Monoamines and their Metabolites in the five Brain Regions of Interest in 40,XY and 39,XY*O Mice.
| Brain region of interest | Karyotype |
Neurotransmitter/metabolite concentration (pg/mg wet brain weight) |
||||||
|---|---|---|---|---|---|---|---|---|
|
Noradrenergic system |
Dopaminergic system |
Serotonergic system |
||||||
| NA | MOPEG | DA | HVA | DOPAC | 5-HT | 5-HIAA | ||
| Frontal cortex | 40,XY (n=8) | 231±19 | 179±14 | 21±2 | 170±12 | 94±6 | 492±46 | 472±30 |
| 39,XY*O (n=8) | 231±13 | 224±16* | 20±3 | 196±18 | 117±6* | 354±44 | 482±11 | |
| Striatum | 40,XY (n=8) | 243±19 | 565±55 | 3675±437 | 2870±105 | 3697±218 | 983±64 | 677±25 |
| 39,XY*O (n=8) | 258±29 | 307±31*** | 6147±853* | 2567±199 | 3245±420 | 1492±128*** | 694±27 | |
| Thalamus | 40,XY (n=8) | 292±32 | 192±11 | 89±14 | 274±17 | 218±18 | 512±144 | 805±37 |
| 39,XY*O (n=8) | 326±23 | 133±15** | 93±16 | 307±24 | 179±17 | 970±172 | 764±44 | |
| Hippocampus | 40,XY (n=8) | 325±22 | 271±25 | 38±7 | 288±166 | 85±5 | 386±26 | 663±28 |
| 39,XY*O (n=8) | 396±40 | 207±15* | 28±2 | 152±8 | 76±4 | 633±50*** | 695±33 | |
| Cerebellum | 40,XY (n=8) | 179±31 | 117±27 | 12±5 | 37±8 | 128±30 | 140±28 | 263±36 |
| 39,XY*O (n=8) | 116±10 | 101±36 | 7±1 | 34±5 | 67±3 | 119±15 | 215±13 | |
*p<0.05, **p<0.01, ***p<0.0033.