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. 2011 Dec 21;37(5):1305–1320. doi: 10.1038/npp.2011.319

Figure 7.

Figure 7

Gap junction blockade in the prefrontal cortex (PFC) induces depressive-like behaviors. (a) The infusion site (coordinates (mm): anteroposterior +3.2, dorsolateral –0.5, depth –4 from Bregma) is marked by an asterisk (*) (Paxinos and Watson, 1998). (b, c) Effects of carbenoxolone (CBX) infusions on sucrose preference test (SPT) and novelty suppressed feeding test (NSFT; n=6/group). Animals received infusions of phosphate-buffered saline (PBS, Vehicle), 1 mM of CBX (low-dose CBX, CBX(L)), 10 mM of CBX (medium-dose CBX, CBX(M)), or 100 mM of CBX (high-dose CBX, CBX(H)) and were consecutively tested in SPT (day 3) and NSFT (day 4). Results are expressed as mean±SEM ratio of sucrose solution vs total liquid consumed (b) and latency to feed in seconds (c). *P<0.05, **P<0.01, ***P<0.001 compared with Vehicle. (d) Effects of connexin 43 (Cx43) mimetic peptide Gap27 and Gap26 infusions on SPT (n=6/group). PBS (Vehicle), scrambled peptide (SP), Gap27, or Gap26 were bilaterally infused and sucrose preference was measured. *P<0.05 compared with SP and #P<0.05, ##P<0.01 compared with Vehicle.