Table A1.

Descriptive information and test statistics for SNPs in ATIC, SHMT2, and SLC46A1 among Caucasian controls, Mayo Clinic, and Duke University.

Gene	Chr	Chr Position (bp)a	SNP rsID	Location	Phase 1						Phases 1 and 2
					P HWEb			MAFc			P HWEb			MAFc
					Mayo	Duke	All	Mayo	Duke	All	Mayo	Duke	All	Mayo	Duke	All
ATIC	2	215898090	rs3772078	Intron	0.88	0.88	0.74	0.19	0.19	0.19	1.00	0.80	0.85	0.20	0.18	0.19
	2	215898265	rs2372536d	Exone	0.23	0.54	0.71	0.32	0.34	0.33	0.32	0.40	0.18	0.32	0.33	0.32
	2	215903416	rs1880586d	Intron	0.77	0.36	0.35	0.48	0.48	0.48	0.94	0.46	0.51	0.49	0.48	0.48
	2	215903526	rs1983462d	Intron	0.58	0.30	0.23	0.32	0.32	0.32	0.77	0.61	0.90	0.32	0.33	0.33
	2	215913412	rs16853826d	Intron	1.00	0.69	0.77	0.13	0.13	0.13	1.00	0.30	0.38	0.13	0.12	0.13
	2	215915470	rs7586969d	Intron	0.42	0.38	0.94	0.39	0.37	0.38	0.47	0.53	1.00	0.39	0.39	0.39
	2	215918481	rs16853834	Intron	0.36	0.49	1.00	0.15	0.15	0.15	0.61	0.89	0.60	0.15	0.16	0.16
	2	215918544	rs1404772	Intron	1.00	0.65	0.78	0.07	0.06	0.06	1.00	0.73	1.00	0.07	0.06	0.06
	2	215925884	rs7604984	3′ Flanking	0.84	0.70	0.94	0.40	0.40	0.40	0.53	0.24	0.19	0.39	0.39	0.39
SHMT2	12	55909088	rs7301155d	5′ Flanking	0.67	–	0.67	0.34	–	0.34	0.70	0.39	0.39	0.34	0.30	0.32
	12	55912849	rs2229716d	Exonf	1.00	1.00	1.00	0.04	0.04	0.04	1.00	0.22	0.67	0.04	0.04	0.04
SLC46A1	17	23743752	rs9894260d	Intron	0.34	0.56	0.19	0.08	0.09	0.08	1.00	0.36	0.36	0.08	0.09	0.08
	17	23747949	rs739439	3′ UTR	0.72	0.16	0.44	0.17	0.20	0.18	0.66	0.38	0.71	0.18	0.19	0.18
	17	23749392	rs2239908	3′ UTR	0.24	0.65	0.23	0.44	0.46	0.45	0.67	0.50	0.40	0.45	0.45	0.45
	17	23753580	rs17719944	Intron	0.55	1.00	0.70	0.09	0.10	0.10	0.80	0.51	0.51	0.09	0.09	0.09

^aBase pairs on genome build 36; UTR, untranslated region.

^bP values from the chi-square test assessing deviation of genotype frequencies among controls from those expected under Hardy–Weinberg Equilibrium.

^cMinor allele frequency.

^dImputed SNPs in Phase 2 samples.

^eNon-synonymous polymorphism.

^fSynonymous polymorphism.