Table A4.
Odds ratios (OR) and 95% CIs for the main effect association between variants in ATIC, SHMT2, and SLC46A1 and ovarian carcinoma among 1,575 Caucasian subjects (Phase 1), Mayo Clinic, and Duke University.
| Gene/SNP rsID | Homozygous major allele (referent) |
Heterozygous |
Homozygous minor allele |
P value (2 df) | Ordinal (per minor allele) |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Cases | Controls | OR (95%CI)a | Cases | Controls | OR (95%CI)a | OR (95%CI)a | P-trend | ||
| ATIC | |||||||||||
| rs3772078 | 415 | 583 | 201 | 279 | 1.0 (0.8–1.3) | 20 | 30 | 0.9 (0.5–1.7) | 0.98 | 1.0 (0.8–1.2) | 0.93 |
| rs2372536 | 304 | 409 | 279 | 399 | 1.0 (0.8–1.2) | 67 | 103 | 0.9 (0.6–1.3) | 0.76 | 0.9 (0.8–1.1) | 0.46 |
| rs1880586 | 167 | 245 | 336 | 473 | 1.0 (0.8–1.3) | 149 | 201 | 1.1 (0.8–1.4) | 0.88 | 1.0 (0.9–1.2) | 0.61 |
| rs1983462 | 319 | 417 | 275 | 417 | 0.9 (0.7–1.1) | 60 | 86 | 0.9 (0.6–1.3) | 0.42 | 0.9 (0.8–1.1) | 0.30 |
| rs16853826 | 497 | 696 | 150 | 210 | 1.0 (0.8–1.3) | 8 | 14 | 0.8 (0.3–2.0) | 0.93 | 1.0 (0.8–1.2) | 0.84 |
| rs7586969 | 259 | 348 | 301 | 436 | 0.9 (0.7–1.1) | 93 | 134 | 0.9 (0.7–1.3) | 0.76 | 1.0 (0.8–1.1) | 0.55 |
| rs16853834 | 442 | 657 | 187 | 241 | 1.1 (0.9–1.4) | 26 | 22 | 1.7 (0.9–3.1) | 0.13 | 1.2 (1.0–1.4) | 0.06 |
| rs1404772 | 568 | 807 | 84 | 108 | 1.1 (0.8–1.5) | 3 | 4 | 1.1 (0.2–5.0) | 0.86 | 1.1 (0.8–1.4) | 0.59 |
| rs7604984 | 242 | 332 | 317 | 442 | 1.0 (0.8–1.2) | 96 | 144 | 0.9 (0.7–1.2) | 0.84 | 1.0 (0.8–1.1) | 0.64 |
| SHMT2 | |||||||||||
| rs7301155 | 121 | 187 | 153 | 202 | 1.2 (0.9–1.6) | 37 | 49 | 1.2 (0.7–1.9) | 0.56 | 1.1 (0.9–1.4) | 0.33 |
| rs2229716 | 601 | 838 | 51 | 79 | 0.9 (0.6–1.3) | 2 | 1 | 2.4 (0.2–27.0) | 0.63 | 0.9 (0.7–1.3) | 0.70 |
| SLC46A1 | |||||||||||
| rs9894260 | 531 | 768 | 111 | 148 | 1.1 (0.8–1.4) | 9 | 3 | 5.4 (1.4–20.5) | 0.04 | 1.2 (0.9–1.5) | 0.14 |
| rs739439 | 435 | 610 | 191 | 283 | 0.9 (0.8–1.2) | 26 | 27 | 1.3 (0.8–2.3) | 0.48 | 1.0 (0.8–1.2) | 0.87 |
| rs2239908 | 197 | 270 | 324 | 473 | 0.9 (0.7–1.2) | 131 | 175 | 1.0 (0.8–1.4) | 0.76 | 1.0 (0.9–1.2) | 0.99 |
| rs17719944 | 534 | 753 | 113 | 157 | 1.0 (0.8–1.3) | 7 | 9 | 1.1 (0.4–3.1) | 0.96 | 1.0 (0.8–1.3) | 0.81 |
aAdjusted for age (<40, 40–49, 50–59, 60–69, and 70+ years) and region of residence (Minnesota, Iowa, Wisconsin, Illinois, North Dakota, South Dakota, and North Carolina).