Table A5.
Odds ratios (OR) and 95% CIs for the main effect association between variants in ATIC, SHMT2, and SLC46A1 and ovarian carcinoma among 2,233 Caucasian subjects (Phases 1 and 2), Mayo Clinic, and Duke University.
| Gene/SNP rsID | Homozygous major allele (referent) |
Heterozygous |
Homozygous minor allele |
P value (2 df) | Ordinal (per minor allele) |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Cases | Controls | OR (95%CI)a | Cases | Controls | OR (95%CI)a | OR (95%CI)a | P-trend | ||
| ATIC | |||||||||||
| rs3772078 | 623 | 810 | 294 | 384 | 1.0 (0.8–1.2) | 32 | 43 | 1.0 (0.6–1.6) | 0.98 | 1.0 (0.8–1.2) | 0.85 |
| rs2372536 | 455 | 583 | 399 | 530 | 1.0 (0.8–1.2) | 109 | 143 | 1.0 (0.7–1.3) | 0.95 | 1.0 (0.9–1.1) | 0.84 |
| rs1880586 | 248 | 348 | 482 | 619 | 1.1 (0.9–1.3) | 235 | 297 | 1.1 (0.9–1.4) | 0.69 | 1.0 (0.9–1.2) | 0.48 |
| rs1983462 | 463 | 573 | 406 | 559 | 0.9 (0.8–1.1) | 98 | 133 | 0.9 (0.7–1.2) | 0.54 | 0.9 (0.8–1.1) | 0.32 |
| rs16853826 | 734 | 957 | 220 | 291 | 1.0 (0.8–1.2) | 14 | 17 | 1.1 (0.5–2.3) | 0.92 | 1.0 (0.8–1.2) | 0.97 |
| rs7586969 | 377 | 469 | 448 | 602 | 0.9 (0.8–1.1) | 141 | 192 | 0.9 (0.7–1.2) | 0.66 | 0.9 (0.8–1.1) | 0.39 |
| rs16853834 | 665 | 902 | 268 | 328 | 1.1 (0.9–1.3) | 34 | 33 | 1.4 (0.8–2.2) | 0.32 | 1.1 (1.0–1.3) | 0.15 |
| rs1404772 | 846 | 1,107 | 118 | 152 | 1.0 (0.8–1.3) | 4 | 5 | 1.1 (0.3–4.1) | 0.99 | 1.0 (0.8–1.3) | 0.98 |
| rs7604984 | 367 | 483 | 455 | 577 | 1.0 (0.9–1.3) | 146 | 202 | 1.0 (0.7–1.2) | 0.75 | 1.0 (0.9–1.1) | 0.87 |
| SHMT2 | |||||||||||
| rs7301155 | 398 | 545 | 404 | 530 | 1.0 (0.9–1.3) | 86 | 114 | 1.0 (0.8–1.4) | 0.87 | 1.0 (0.9–1.2) | 0.64 |
| rs2229716 | 902 | 1,175 | 63 | 86 | 0.9 (0.7–1.3) | 2 | 2 | 1.1 (0.1–7.7) | 0.92 | 0.9 (0.7–3.3) | 0.73 |
| SLC46A1 | |||||||||||
| rs9894260 | 799 | 1,056 | 152 | 202 | 1.0 (0.8–1.2) | 13 | 6 | 3.1 (1.1–8.3) | 0.08 | 1.1 (0.9–1.3) | 0.44 |
| rs739439 | 627 | 845 | 298 | 281 | 1.0 (0.9–1.3) | 40 | 39 | 1.4 (0.9–2.2) | 0.36 | 1.1 (0.9–1.3) | 0.25 |
| rs2239908 | 267 | 370 | 495 | 642 | 1.1 (0.9–1.3) | 203 | 251 | 1.1 (0.9–1.4) | 0.73 | 1.1 (0.9–1.2) | 0.43 |
| rs17719944 | 784 | 1,040 | 174 | 211 | 1.1 (0.9–1.4) | 8 | 13 | 0.9 (0.4–2.1) | 0.66 | 1.1 (0.9–1.3) | 0.53 |
aAdjusted for age (<40, 40–49, 50–59, 60–69, and 70+ years) and region of residence (Minnesota, Iowa, Wisconsin, Illinois, North Dakota, South Dakota, and North Carolina).