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Key effects of substance P in dental pulp.
| Healthy tissues |
|---|
| Maintenance of tissue homeostasis [6, 27, 28] |
| Inflamed tissues |
| Vasodilatatory response [6, 7] |
| Histamine release [29] |
| Increase in blood flow [29] |
| Increase in vascular permeability [29] |
| Increase in blood pressure [29] |
| Synthesis of proinflammatory cytokines [30, 31] |
| Chemotaxis of inflammatory cells [30] |
| Sensitisation of nociceptors [7] |
