Table 2.
Comparison of phenotypes of Mkk4 flox/flox Nestin-Cre and Mkk7 flox/flox Nestin-Cre mice.
| Phenotype | Mkk4flox/flox Nestin-Cre [37] | Mkk7flox/flox Nestin-Cre [38] |
|---|---|---|
| Neuronal JNK activity | Suppressed | Suppressed |
| Age of lethality | Around 3 weeks old | At birth |
| Brain ventricle size at E18.5 | Not reported | Enlarged |
| Striatum | Not reported | Reduced |
| Axon tracts (E18.5) | Unaffected | Greatly reduced |
| Axon tracts (postnatal) | Less fasciculated | Not determined |
| Intermediate filaments | Not reported | Accumulate in axons |
| Autophagic vacuoles | Not reported | Accumulate |
| JNK phosphorylation in axons | Not reported | Suppressed |
| L1-positive axons (E18.5) | Unaffected | Reduced |
| TAG-1-positive axons (E18.5) | Not reported | Reduced |
| Apoptosis | Unaffected | Unaffected |
| Cortical layer markers | Not reported | Expressed |
| Radial migration | Delayed | Delayed |
| Phosphorylation of c-Jun | Suppressed | Suppressed |
| Phosphorylation of NF-H | Suppressed | Suppressed |
| Phosphorylation of MAP1B | Suppressed | Suppressed |
| Phosphorylation of DCX | Unaffected | Suppressed |