Table 2.
Data on mRNA levels of osteoclast specific genes and RANK/RANKL/OPG genes in OP and OA
| Gene symbol | Gene name | OP (n = 23) | OA (n = 31) | OP/OAa | p valueb |
|---|---|---|---|---|---|
| Osteoclast specific genes | |||||
| OSCAR | Osteoclast associated immunoglobulin-like receptor | 0.574(0.345;0.854) | 1.002(0.732;1.339) | 0.54 | 0.002* |
| ITGB3 | β3 integrin | 0.241(0.074;0.586) | 0.285(0.143;0.994) | 0.85 | 0.231 |
| CTSK | Cathepsin K | 0.288(0.121;1.109) | 0.263(0.136;0.555) | 1.10 | 0.786 |
| ACP5 | Tartrate resistant acid phosphatase (TRAP) | 0.270(.128;1.011) | 0.147(0.073;0.259) | 1.84 | 0.049* |
| CALCR | Calcitonin receptor | 0.223(0.138;0.644) | 0.860(0.482;1.562) | 0.26 | < 0.0005** |
| RANK/RANKL/OPG genes | |||||
| TNFRSF11A | Receptor activator of nuclear factor κB (RANK) | 1.580(0.687;3.939) | 0.573(0.355;1.038) | 2.76 | 0.002* |
| TNFSF11 | Receptor activator of nuclear factor κB ligand (RANKL) | 0.528(0.076;1.038) | 0.091(0.027;0.253) | 5.80 | < 0.0005** |
| TNFRSF11B | Osteoprotegerin (OPG) | 0.699(0.410;0.914) | 0.776(0.308;1.615) | 0.90 | 0.681 |
| TNFSF11/TNFRSF11A | RANKL/RANK | 0.241(0.083;0.928) | 0.140(0.064;0.271) | 1.72 | 0.076 |
| TNFSF11/TNFRSF11B | RANKL/OPG | 0.448(0.295;1.601) | 0.112(0.075;0.193) | 4.00 | < 0.0005** |
Values are medians(25th;75th percentile). All mRNA values were normalized to the geometric mean of GAPDH and RPLP0 mRNA.
aGene expression ratio of medians in osteoporotic (OP) versus osteoarthritic (OA) patients.
bComparisons were assessed by the Mann-Whitney U test. *p < 0.05, **p < 0.001.