Table 2.
Age and sex standardized incidence of psychotic syndromes over three time periods
| Diagnosis (ICD-10) | TP1 (1978–80) Standardized incidence ratea (95% CI) | TP2 (1992–94) Standardized incidence ratea (95% CI) | TP3 (1997–99) Standardized incidence ratea (95% CI) | IRR for linear change in incidence per year (95% CI) | LRT test for change in incidence rate over time |
|---|---|---|---|---|---|
| All psychoses (F10–33) | 23.4 (18.6–28.2) | 26.0 (21.2–30.8) | 27.1 (22.3–31.9) | 1.01 (0.99–1.02) | 0.19 |
| Non-affective psychoses (F20-29) | 16.8 (12.8–20.9) | 17.1 (13.2–21.0) | 16.7 (12.9–20.5) | 1.00 (0.98–1.02) | 0.96 |
| Of which | |||||
| Schizophrenia (F20) | 13.2 (9.6–16.8) | 8.2 (5.5–10.8) | 8.9 (6.2–11.6) | 0.98 (0.96–1.00) | 0.04 |
| Other non-affective psychoses (F21–29) | 3.6 (1.7–5.5) | 9.0 (6.1–11.8) | 7.8 (5.2–10.4) | 1.04 (1.01–1.07) | 0.01 |
| Substance-induced psychoses (F10–19) | 0.2 (0.0–0.5) | 1.9 (0.7–3.1) | 3.6 (1.9–5.2) | 1.15 (1.05–1.25) | <0.01 |
| Affective psychoses (F30–33) | 6.4 (3.9–8.9) | 7.0 (4.5–9.4) | 6.8 (4.4–9.3) | 1.00 (0.98–1.03) | 0.73 |
| Of which | |||||
| Manic psychoses (F30–31) | 2.2 (0.7–3.8) | 3.3 (1.6–5.1) | 3.0 (1.4–4.6) | 1.02 (0.98–1.06) | 0.35 |
| Depressive psychoses (F32–33) | 4.2 (2.1–6.2) | 3.6 (1.8–5.4) | 3.8 (2.0–5.7) | 0.99 (0.96–1.02) | 0.74 |
aDirectly standardized to the age and sex stratified population of England and Wales from 2001 census. Rates expressed per 100 000 person-years.