Table 1. The relative fitness cost of M184V was previously calculated 16, and used as a calibration factor to estimate the relative fitness costs for the other 9 DRMS (see Methods). Ranges reflect heterogeneity in the data. Values (median and interquartile range (IQR)) for R0’s and detection times were estimated using uncertainty analyses. The maximum detection time was 8 years, because individuals in resource-rich countries are on treatment by then.
| DRM | Relative fitness cost (%) | R0 Median (IQR) | Detection Time (years) Assay Sensitivity (20%) Median (IQR) | Assay Sensitivity (1%) Median (IQR) |
|---|---|---|---|---|
| K70R | 0.11–0.23 | 1.5 (1.5–1.6) | >8 | >8 |
| Y181C | 0.17–0.35 | 1.4 (1.3–1.5) | 7.8 (6.8–8.0) | >8 |
| K219Q | 0.40–0.80 | 0.74 (0.62–0.84) | 3.7 (3.2–4.3) | 5.3 (4.6–6.2) |
| L74V | 0.57–1.2 | 0.51 (0.43–0.61) | 2.7 (2.4–3.1) | 3.8 (3.3–4.5) |
| D67N | 1.1–2.1 | 0.27 (0.22–0.32) | 1.5 (1.3–1.8) | 2.1 (1.9–2.5) |
| M41L | 1.2–2.5 | 0.21 (0.18–0.25) | 1.3 (1.1–1.5) | 1.8 (1.5–2.1) |
| K103N | 1.7–3.5 | 0.14 (0.12–0.18) | 0.97 (0.84–1.1) | 1.3 (1.1–1.6) |
| T215Y | 3.7–7.3 | 0.05 (0.04–0.06) | 0.47 (0.40–0.56) | 0.63 (0.55–0.75) |
| M184V | 4.0–8.016 | 0.04 (0.04–0.05) | 0.43 (0.37–0.52) | 0.58 (0.50–0.70) |
| K65R | 8.0–16 | 0.02 (0.02–0.04) | 0.21 (0.17–0.25) | 0.28 (0.23–0.33) |