Table 2. Results from 110,000 simulations of the stochastic transmission chain model; 10,000 simulations were conducted for each DRM and the wild-type strain. Values of the relative fitness costs were used in the within-host model to track viral dynamics within each individual in a transmission chain.
| DRM | Simulations where no transmission occurred (%) | Expected Cluster Size (if transmission occurs) | Expected Chain Length (if transmission occurs) | Relative fitness cost used in simulation (%) |
|---|---|---|---|---|
| Wild-type | 18 | 76.4 | 7.82 | −− |
| K70R | 20 | 63.0 | 7.51 | 0.17 |
| Y181C | 23 | 48.3 | 7.04 | 0.26 |
| K219Q | 47 | 6.55 | 3.05 | 0.60 |
| L74V | 58 | 3.70 | 1.97 | 0.86 |
| D67N | 75 | 2.59 | 1.37 | 1.6 |
| M41L | 80 | 2.42 | 1.28 | 1.9 |
| K103N | 86 | 2.27 | 1.18 | 2.6 |
| T215Y | 95 | 2.09 | 1.07 | 5.5 |
| M184V | 96 | 2.06 | 1.05 | 6.0 |
| K65R | 96 | 2.05 | 1.04 | 12 |