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. Author manuscript; available in PMC: 2013 Apr 15.
Published in final edited form as: Biochem Pharmacol. 2012 Jan 11;83(8):1084–1103. doi: 10.1016/j.bcp.2012.01.002

Figure 2.

Figure 2

Schematic representation of transcriptional regulation of BCRP expression. Transcription factors that bind to cis elements upstream of the BCRP E1B/C promoter with subsequent activation or repression of the promoter are depicted diagrammatically. Signaling pathways and extracellular stimuli that stimulate binding of the transcription factors are also shown. The position of the various experimentally verified BCRP cis regulatory elements in relation to the transcription start site of the BCRP E1B/C first exon are also shown. The trans and cis regulatory elements were compiled from the literature cited in Section 2e, “Regulation of BCRP expression and function” of this review.