Table 1.
Prevalence and duration of kidney organ failure (‘standard-exposure’ group vs ‘high-exposure’ group)
| Standard-exposure group (N=596) | High-exposure group (N=604) | p Value | |
| eGFR*: number of days (% of days from days 1 to 28 with values): | |||
| Moderately–severely impaired (eGFR: ≤60 ml/min/1.73 m2) | 3016 (43.4) | 3672 (48.1) | <0.0001 |
| Severely impaired (eGFR ≤30 ml/min/1.73 m2) | 1445 (20.8) | 1910 (25.0) | <0.0001 |
| Severely impaired (eGFR ≤30 ml/min/1.73 m2), days from days 1 to 14 | 984 (20.0) | 1253 (23.5) | <0.0001 |
| ‘RIFLE’ criteria, number of patients (%) within days 1–28 | |||
| ’R’ reached | 170 (28.5) | 209 (34.6) | 0.02 |
| ‘I’ reached | 75 (12.6) | 92 (15.2) | 0.19 |
| ‘F’ reached | 121 (20.3) | 150 (24.8) | 0.06 |
| ‘R’ or death | 298 (50.0) | 327 (54.1) | 0.15 |
| ‘I’ or death | 234 (39.3) | 252 (41.7) | 0.39 |
| ‘F’ or death | 270 (45.3) | 287 (47.5) | 0.44 |
| Urea | |||
| Patients with a urea level ever ≥20 mmol/l (days 1–28), n (%) | 217 (37.4) | 253 (43.4) | 0.04 |
eGFR was assessed using the Cockcroft and Gault method (Ref: Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31–41). Actual measured creatinin values were used. If using the ‘last observation carried forward’ approach regarding creatinin measurement to take into account that patients who died in renal failure should be counted as such did not change the signal or the statistics of these analyses. ‘R’: Risk, ‘I’: Injury, ‘F’: Failure. Presence of renal failure according to ‘RIFLE’ was assessed using the guidelines developed by the acute dialysis quality initiative (http://www.adqi.net).
eGFR, estimated glomerular filtration rate.