FIGURE 1.

Structure of human Fn (at top) and S. aureus FnBP. FnBPA (shown here) has 11 Fn-binding repeats, each ∼40 residues (14). FnBPB is missing either the second or the third repeat (13). W, wall-spanning region; M, membrane-spanning region. The bottom panel shows the amino acid (AA) sequence of FnBPA-5 and -9 from the wild-type strain of S. aureus (NCTC 8325). Red letters highlight the location of three polymorphisms (E652D, H782Q, and K786N) that were statistically more common in FnBPA from S. aureus isolated from patients with infected cardiovascular devices (19).