TABLE 1.
Dissociation rate constants (koff) and bond lifetimes (1/koff; τ) for ∼10- and ∼80-bond clusters of Fn in complex with Fn receptors on living S. aureus
These values were determined by probing the binding reaction on 46 different S. aureus isolates. These isolates came from two different groups of human patients, all of whom had cardiovascular implants (e.g. prosthetic heart valve, permanent pacemaker, or defibrillator). One group of patients had S. aureus infection of the implanted cardiac device (CDI), whereas the other group (CDU) did not have an infected device, although S. aureus were present in their blood. p values were calculated with the Student's t test.
| Dissociation rate constant (koff) and bond lifetime (1/koff) | Clinical isolates of S. aureus |
p value | ||
|---|---|---|---|---|
| Cardiac device infected (n = 26) | Cardiac device uninfected (n = 20) | |||
| ∼10-Bond cluster | koff (s−1) | 0.56 | 1.04 | <0.05 |
| τ (s) | 1.79 | 0.96 | ||
| ∼80-Bond cluster | koff (s−1) | 0.014 | 0.029 | <0.05 |
| τ (s) | 69.47 | 34.02 | ||