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Cdc37 in IRE1α regulation induced by Hsp90 inhibition. A, response to Hsp90 inhibition in control (shLuci) and Cdc37 knockdown (shCdc37) HeLa cells expressing IRE1α-WT was measured by immunoblots for p-IRE1α and IRE1α as indicated or by XBP-1 pro-RNA splicing by RT-PCR (bottom panel). B, response to Hsp90 inhibition in control (shLuci) and Cdc37 knockdown (shCdc37) HeLa cells expressing the IRE1αKD mutant was measured by XBP-1 pro-RNA splicing.
