Tannic acid treatment prevents behavioral impairment in PSAPP mice. PSAPP mice received oral vehicle (PSAPP-V, n = 16) or TA (PSAPP-TA, n = 16) treatment, and wild-type mice were given vehicle (WT-V, n = 16) or TA (WT-TA, n = 16) orally for 6 months beginning at 6 months of age, and subjected to behavioral testing at 12 months of age. To examine cognitive status when dosing started, untreated 6-month-old PSAPP mice (PSAPP-6M, n = 12) and WT mice (WT-6M, n = 12) were included in the behavioral analyses. A, locomotion and rearing scores obtained from open field activity testing are shown. B, recognition index (%) in the object recognition test is shown (left, training phase; right, retention test phase). C, Morris water maze test data are shown from the submerged platform (learning phase) and from D, a single 60-s probe trial test (conducted 1 day after termination of the learning phase). All statistical comparisons are versus PSAPP-V mice.