FIGURE 7.

Effects of mutations in RACK1 and Pkd2L1. A and B, PKd2L1 was expressed in oocytes with or without co-expression of a RACK1 mutant. A, averaged Ca²⁺-activated currents measured at −50 mV with each group from 5 to 16 different oocytes. ** and *** indicate p < 0.01 and p < 0.001, respectively. B, averaged ⁴⁵Ca tracer uptake from three independent experiments using uptake solution. Error bars indicate S.E. C, effect of RACK1 on the function of Pkd2L1 mutants. Pkd2L1 missense mutants were expressed in oocytes with or without co-expression of RACK1. Shown are averaged Ca²⁺-activated currents measured at −50 mV with each group from 7 to 11 different oocytes.