TABLE 1.
Inhibition of SFT on subtypes A–C primary HIV-1 strains
The inhibitory activity of each peptide was determined in triplicate by a single cycle infectivity assay. The data were derived from the results of three independent experiments and are expressed as means ± S.D.
| Pseudovirus | Subtype | Co-Ra | IC50 |
|
|---|---|---|---|---|
| SFT | T20 | |||
| nm | ||||
| 92RW020 | A | R5 | 1.73 ± 0.63 | 23.72 ± 8.73 |
| 92UG037.8 | A | R5 | 1.88 ± 0.30 | 4.00 ± 0.85 |
| SF162 | B | R5 | 3.87 ± 1.07 | 41.69 ± 6.53 |
| AC10.0.29 | B | R5 | 1.59 ± 0.30 | 8.88 ± 1.24 |
| TRO.11 | B | R5 | 21.18 ± 2.76 | 279.00 ± 126.15 |
| pREJO4541 | B | R5 | 1.05 ± 0.10 | 94.02 ± 11.29 |
| pRHPA4259 | B | R5 | 24.41 ± 0.66 | 298.50 ± 22.91 |
| SC422661.8 | B | R5 | 1.72 ± 0.17 | 13.73 ± 0.36 |
| pCAAN5342 | B | R5 | 18.66 ± 0.64 | 588.55 ± |
| ZM197M.PB | C | R5 | 4.84 ± 0.73 | 71.56 ± 5.32 |
| ZM109F.PB | C | R5 | 4.68 ± 1.35 | 76.38 ± 2.69 |
| Du172.17 | C | R5 | 1.51 ± 0.66 | 10.73 ± 6.53 |
| Du422.1 | C | R5 | 1.66 ± 0.17 | 29.13 ± 4.13 |
| CAP45.2.00. | C | R5 | 6.51 ± 1.19 | 99.26 ± 2.61 |
a Co-R means coreceptor use.