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. 2012 Jan 6;287(9):6284–6295. doi: 10.1074/jbc.M111.293001

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — S49 (OS 4–15) cells gained a robust RVI response, sensitive to inhibition with flufenamic acid. A, S49 (OS 4–15) cells treated with 250 mOsm mannitol showed a robust inherent RVI compared with the S49 (Neo) cells. B, in contrast, no change in the ability of S49 (OS 4–15) cells was observed in regards to their inherent RVD response upon hypoosmotic treatment. C, RVI response in S49 (OS 4–15) cells was inhibited using FFA (200 μm), a known inhibitor of hypertonic-induced cation channels, or the AKT inhibitor (AKTi; 5 μm). Data represent the mean (± S.E.) of 3 to 4 independent experiments. *, p < 0.001; **, p < 0.01; ***, p < 0.05 versus control.