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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Pflugers Arch. 2011 Dec 8;463(4):537–548. doi: 10.1007/s00424-011-1061-z

Figure 3.

Figure 3

Lack of effect of chronic β-blockade on voltage- or time-dependent characteristics of ITO. Open symbols are data (means±SEM) from non-β-blocked patients (n=27-32 cells, 11-15 patients); filled symbols from β-blocked patients (17-29 cells, 6-15 patients). (A) Boltzmann curves-fits for voltage-dependent activation (_) and inactivation (---). (B) Bi-exponential curve-fits showing time-dependent ITO inactivation at +60 mV. Inset shows amplitudes of fast and slow inactivation phases, respectively. (C) Mono-exponential curve-fits showing ITO reactivation. Inset is an enlarged version of main graph at short interpulse intervals of the 2-pulse activation protocol. (D) ITO rate-dependence: normalised steady-state (8th pulse) ITO density vs stimulation rate.