D1 receptor mRNA expression in prefrontal cortex and striatum. a–f, There were positive correlations between risk-taking and D1 mRNA expression in insular cortex and nucleus accumbens shell, such that high D1 expression predicted high risk-taking (c, f). There was no significant relationship between risky decision-making and D1 expression in orbitofrontal cortex (a), medial prefrontal cortex (b), dorsal striatum (d), or nucleus accumbens core (e). All bar graphs represent means + SEM. *p < 0.05, Tukey's HSD post hoc test.