Numerical simulation: mechanism of scroll filament meandering during AF. (A) Diagram illustrating the spatial dimensions of the atrial model. (B) Snapshot of 3D simulation movie. Red, scroll wave filament. (C) Quantification of filament trajectory using α as the meandering angle. (D) Schematic of simulated atrial models, trajectories, and relative rates of filament meandering over eight petals/1 s of SW meandering. (E) Plot of Δα in NH, PtAF-3, and PtAF-4: angular meandering of filament decreases under conditions of heterogeneous stretch.