Table 3.

Changes in relative intensities of metabolites in response to NAC

		Survivors (n = 44)		Non-survivors (n = 19)
Metabolite	ppm	Mean ± SE	p-value	Mean ± SE	p-value
Lactate	4.08-4.13	2.8 ± 15.3	0.815	97.1 ± 26.4	0.004**
Glycine	3.54-3.56	-19.6 ± 8.0	0.047*	0.8 ± 14.3	0.601
GPC	3.22-3.24	-59.6 ± 14.6	< 0.001**	-11.8 ± 15.7	0.469
PC	3.21-3.22	-95.4 ± 24.3	< 0.001**	-67.4 ± 44.2	0.227
Cho	3.20-3.21	-16.6 ± 6.3	0.013*	-17.8 ± 6.3	0.084
tCho	3.20-3.24	-167.2 ± 36.7	< 0.001**	-95.3 ± 57.5	0.091
Taurine	3.40-3.43	-0.8 ± 13.2	0.861	6.9 ± 12.5	0.398
β-Glucose	4.61-4.64	17.8 ± 5.1	0.002**	-0.2 ± 8.8	0.841

The values (post- minus pre-treatment) of relative intensities are integrated peak areas from spectra normalized to equal total areas. Wilcoxon sign rank tests were used for paired statistical analyses. *p < 0.05, ** p < 0.01