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Frequencies of the top five D → O and O → D disease mutations from the UniProt database
| Substitution | D → O disease mutations (%) | Substitution | O → D disease mutations (%) |
|---|---|---|---|
| R → W | 13.1 | L → P | 11.9 |
| R → C | 10.3 | C → R | 6.6 |
| R → H | 7.6 | G → R | 6.1 |
| E → K | 6.7 | W → R | 4.1 |
| R → Q | 6.3 | F → S | 3.6 |
