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Functional properties of channels supported by the wild-type and mutant HA-α1B/α2δ/β3 subunit combinations expressed in Xenopus oocytes
| HA-α1B | Peak current (μA) | Peak current/end of 50 msec pulse |
|---|---|---|
| HA-α1B-WT | 0.8 ± 0.4 | 2.8 ± 0.49 |
| HA-α1B-D2334X | 0.59 ± 0.09 | 2.0 ± 0.18 |
| HA-α1B-S2176X | 0.39 ± 0.04 | 2.8 ± 0.67 |
| HA-α1B-PXXP-A/D2334X | 0.45 ± 0.06 | 3.0 ± 0.66 |
| HA-α1B-rNC2 | 0.67 ± 0.1 | 2.1 ± 0.34 |
n ≥ 5 for each group. WT, Wild type.
