Table 2.
l-DOPA, dopamine and tetrabenazine levels in blood and/or brains of experimental mice (30 min after drug feeding)
| Tissue | Group | Measurements |
||
|---|---|---|---|---|
| l-DOPA | Dopamine | TBZ | ||
| Blood (ng/ml) | Vehicle | |||
| l-DOPA | 6997 ± 1908 | |||
| l-DOPA/TBZ | 15269 ± 1857* | 13 ± 5 | ||
| Striata (ng/gm) | Vehicle | 4705 ± 1158 | ||
| l-DOPA | ND | 10656 ± 1529** | ||
| l-DOPA/TBZ | ND | 5911 ± 2180* | 10 ± 3 | |
| Brain hemisphere (ng/gm) | Vehicle | 311 ± 23 | ||
| l-DOPA | 1072 ± 181 | 840 ± 77 | ||
| l-DOPA/TBZ | 1127 ± 89 | 662 ± 49 | 19 ± 2 | |
Data are expressed as their average ± SEM (n = 5). Units are ng/ml (blood) and ng/gm (brain tissue). *Statistically different (p < 0.05) from l-DOPA alone. **Statistically different (p < 0.05) from control.