Table 1.

Summary of features in past medical history and family history suggesting the presence of hereditary cancer susceptibility syndromes in adrenocortical carcinoma (ACC) patients.

Features suggesting the presence of a hereditary cancer susceptibility syndrome in ACC patients
Personal history
Metachronous ACC
Bilateral ACC
Multiple primary tumors in organs other than the adrenal gland
Other rare cancers in the same patient
Development of ACC from prior known precursor lesion
ACC diagnosed during childhood
Other congenital defects
Other endocrine diseases (e.g. pHPT)
Cutaneous lesions commonly found in hereditary cancer susceptibility syndromes
Family History
Unusual high number of family members affected with cancers
Family history of ACC
Family history of other rare cancers
Family history of known hereditary cancer susceptibility syndromes