Skip to main content
. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: J Neurosci Res. 2011 Nov 8;90(3):706–714. doi: 10.1002/jnr.22786

Figure 5.

Figure 5

Neuronal loss is not associated with apoptosis or gliosis but with glycogen accumulation.

A. Apoptosis was not evident as detected by TUNEL staining in the CA3 region of the hippocampus where neuron loss was conspicuous.

B. Gliosis was not detected by GFAP immunostaining of serial sections in the same region.

C. Large vacuoles were found in neurons in the frontal lobe of transgenic brains. These vacuoles appeared to push the nucleus and cytoplasm to the boundary of the cell and were stained positive for PAS (arrow).