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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: J Neurosci Res. 2011 Nov 8;90(3):706–714. doi: 10.1002/jnr.22786

Figure 6.

Figure 6

AUUCU repeats form RNA aggregates and sequester hnRNP K in transgenic mouse brain.

A. In sagittal sections of 6 month-old transgenic mouse brains, RNA fluorescent in situ hybridization (FISH) showed distinct RNA aggregates (red) in neurons of the cortex, pontine nuclei and hippocampus. Similar sections of the brain of 6 month-old wild-type littermates showed DAPI stain of nuclei but no red FISH signal (not shown).

B. Co-localization of AUUCU-containing repeats (red) with hnRNPK (green) in the pontine nuclei of transgenic mice.

C. Co-localization of expanded AUUCU repeats (red) and hnRNP K (green) in the hippocampus of transgenic mice.