Table 1.
Comparison of Ataxin-10 Expression to Transgenic LacZ Expression
| Regions of Brain | Human | Mouse | SCA10 Transgenic |
|---|---|---|---|
| ATXN10 | ATXN10 | LacZ | |
| Olfactory Bulb | ND | ++ | ++ |
| Cerebral Cortex | 0/+ | 0/+ | +++ |
| Striatum | 0 | 0/+ | ND |
| Locus Ceruleus | + | + | +++ |
| Substantia Nigra | 0 | 0 | ++ |
| Midbrain Raphe | +/++ | ++ | ND |
| Pontine Nuclei | +/+++ | ++/+++ | +++ |
| Nuclei Cuneatus | +++ | ND | +++ |
| Vestibular Nuclei | ++ | ++ | + |
| Olivary Nuclei | ++ | ++ | ++ |
| Hypoglossal Nuclei | +/++ | ND | +++ |
| Purkinje Cells | +/++ | +/+++ | + |
| Deep Cerebellar Nuclei | ND | +++ | ++ |
| Spinal Motor Neurons | + | + | ND |
| 0 - no observable staining | |||
| + - +++, semi-quantitative staining | |||
| ND- not determined | |||
Modified from Marz et al. (4)