FIG. 3.

B6.D2 male mice have inherently relatively smaller hearts and smaller heart mass to total body mass ratios than do B6 mice. Data were combined for the B6 and B6;Apoe^−/− mice and B6.D2 and B6.D2;Apoe^−/− mice, respectively. Heart mass was calculated from ultrasound biomicroscopy measurements for time points 8, 12, 16, 20, and 28 weeks following the long-term BaP exposure protocol 2 (Fig. 1C). Body (A and D) and heart (B and E) masses were determined to calculate heart mass/body mass ratios (C and F) over time (A, B, and C) and cumulatively, in which the heart and body masses for each mouse at each of the five time points in a given strain were summed and divided by the total number of mice for that strain (D, E, and F). Error bars represent SEM. Numbers of mice for each experimental group are shown (G).