FIG. 4.

Male B6;Apoe^−/− mice develop atherosclerotic plaque earlier than do B6.D2;Apoe^−/− mice. Shown are representative descending aorta from B6;Apoe^−/− mice (A) and B6.D2;Apoe^−/− mice (B). Thoracic and descending aorta were harvested from control and BaP-exposed mice sacrificed at 5, 7, and 15 weeks of age and assayed for atherosclerotic plaque by staining with oil red O. The mice were exposed to BaP as depicted in BaP exposure protocol 1 (Fig. 1B). The arrows are pointing at some stained plaque.