TABLE 3.
Immune Response Genes Involved in Atherosclerosis Are Expressed At Greater Levels in BaP-Exposed B6 Mice Relative to B6.D2 Mice (p Value ≤ 0.05)
| Gene symbol | Fold change B6/B6.D2 | AHR response element |
| SERPINA3G | 2.27 | |
| H2-AB1 | 2.15 | |
| H2-AA | 2.11 | |
| H2-EB1 | 2.07 | |
| PSMB9 | 1.81 | ✓ |
| C1QB | 1.75 | |
| LY86 | 1.74 | |
| CXCL9 | 1.73 | |
| OAS1G | 1.69 | |
| C1QA | 1.63 | ✓ |
| C1QC | 1.55 | |
| C2 | 1.55 | |
| FCGR2B | 1.54 | |
| CD79B | 1.50 | |
| H2-M2 | 1.50 | |
| CFP | 1.43 | |
| H2-M3 | 1.43 | |
| CD86 | 1.42 | |
| LOC100044190 | 1.42 | |
| PSMB8 | 1.42 | |
| TLR7 | 1.39 | |
| CLEC4N | 1.37 | |
| CIITA | 1.35 | |
| CD34 | 1.34 | ✓ |
| CD40 | 1.27 | |
| 2610524H06RIK | 1.26 | |
| TNFAIP8L2 | 1.26 | |
| IL7 | 1.24 | |
| CCR5 | 1.18 | |
| IL18 | 1.18 | |
| TLR6 | 1.18 | |
| CD180 | 1.16 | |
| CXCL10 | 1.15 | |
| TLR1 | 1.15 | ✓ |
| BTLA | 1.14 | |
| FOXP3 | 1.11 | |
| FTH1 | 0.94 | |
| TESC | 0.82 | |
| NLRX1 | 0.79 | |
| RB1 | 0.76 | ✓ |
| G6PDX | 0.71 | |
| HOXB4 | 0.69 | ✓ |
| HDAC5 | 0.68 | |
| HSPD1 | 0.65 | ✓ |
| TXNRD2 | 0.63 | |
| DNAJA3 | 0.46 | ✓ |
Notes. B6, high-affinity AHR mouse strain; B6.D2, low-affinity AHR mouse strain. Mice (all male) were fed a Western diet. n = 4 mice per experimental group. Mice were administered 10 mg/kg/day BaP in corn oil five times a week by gavage.