TABLE 5.
Biological Pathways Associated With Differentially Expressed Genes Unique to B6 Compared With B6.D2 Mice Exposed to BaP
| Biological pathway/term | p Value | FDR |
| GO:0009987∼cellular process | 1.70 × 10−14 | 3.08 × 10−11 |
| GO:0007517∼muscle organ development | 2.57 × 10−6 | 4.67 × 10−2 |
| GO:0003012∼muscle system process | 1.25 × 10−5 | 2.27 × 10−2 |
| GO:0001944∼vasculature development | 1.40 × 10−5 | 2.54 × 10−2 |
| GO:0001568∼blood vessel development | 1.83 × 10−5 | 3.32 × 10−2 |
| GO:0044237∼cellular metabolic process | 4.71 × 10−5 | 8.54 × 10−2 |
| GO:0006936∼muscle contraction | 4.85 × 10−5 | 8.79 × 10−2 |
| GO:0014706∼striated muscle tissue development | 5.09 × 10−5 | 9.22 × 10−2 |
| GO:0060537∼muscle tissue development | 5.77 × 10−5 | 1.05 × 10−1 |
| GO:0044238∼primary metabolic process | 6.81 × 10−5 | 1.23 × 10−1 |
| GO:0042592∼homeostatic process | 9.89 × 10−5 | 1.79 × 10−1 |
| GO:0048514∼blood vessel morphogenesis | 1.88 × 10−5 | 3.40 × 10−1 |
| GO:0008152∼metabolic process | 1.91 × 10−4 | 3.47 × 10−1 |
| GO:0055001∼muscle cell development | 2.30 × 10−4 | 4.16 × 10−1 |
| GO:0006066∼alcohol metabolic process | 2.41 × 10−4 | 4.36 × 10−1 |
| GO:0006006∼glucose metabolic process | 2.46 × 10−4 | 4.45 × 10−1 |
| GO:0006937∼regulation of muscle contraction | 2.50 × 10−4 | 4.52 × 10−1 |
| GO:0030239∼myofibril assembly | 4.11 × 10−4 | 7.43 × 10−1 |
| GO:0031032∼actomyosin structure organization | 4.78 × 10−4 | 8.64 × 10−1 |
| GO:0005996∼monosaccharide metabolic process | 5.03 × 10−4 | 9.08 × 10−1 |
Notes. B6, high-affinity AHR mouse strain; B6.D2, low-affinity AHR mouse strain; FDR, false discovery rate. Mice (all male) were fed a Western diet. n = 5 mice per experimental group. Mice were administered 10 mg/kg/day BaP in corn oil five times a week by gavage.