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. 2012 Apr;53(4):755–766. doi: 10.1194/jlr.M022178

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Copyright © 2012 by the American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 3. — Kr-pok further increases transcriptional activation of the FASN gene by SREBP-1c. A–C: Kr-pok enhances transcriptional activation of the artificial pGL2-6×[SRE]Luc or FASN promoter-Luc with SREBP-1c in HEK293A cells cotransfected with expression vectors of SREBP-1c (25 ng) and Kr-pok (25, 125, and 500 ng). Reporter activity was normalized with cotransfected β-galactosidase activity or protein concentration for transfection efficiency. The data presented are the average of three independent assays. Bars represent standard deviation. D, E: RT-PCR and Western blot analysis. HEK293A cells were cotransfected with the expression vector of FLAG-Kr-pok and/or Myc-SREBP-1c. The cell extracts were analyzed for FASN expression. Tss (+1), transcription start site; GAPDH, control.