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. 2012 Mar 19;7(3):e33702. doi: 10.1371/journal.pone.0033702

Figure 1. Fibrocytes are markedly elevated and activated in the circulation of patients with SCD at baseline compared to healthy African American controls.

Figure 1

A) fibrocytes defined as CD45+Col1+ cells were elevated in number in the circulation of patients with SCD, as compared to control subjects. B–D) demonstrates that fibrocytes in the circulation of patients with SCD, as compared to control subjects express a chemokine receptor hierarchy (i.e., CXCR4+>CCR2+>CCR7+). E–F) demonstrates that fibrocytes in the circulation of patients with SCD, as compared to control subjects represent an activated phenotype of αSMA+ and pSmad2/3+ cells, respectively, compatible with fibrocytes pre-systemically activated by TGF-b.