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. 2012 Mar 19;7(3):e33702. doi: 10.1371/journal.pone.0033702

Figure 3. NY1DD SCD mice demonstrated increased deposition of extracellular matrix in their lungs under baseline conditions.

Figure 3

A) NY1DD SCD mice, as compared to appropriate strain (C57Bl/6) and age-matched mice, demonstrate elevated levels of total collagen in their lungs under baseline (normoxia) conditions. The levels of total collagen in the lungs of NY1DD mice at baseline are equivalent to C57Bl/6 mice exposed to the pulmonary fibrotic agent, bleomycin, at day 16. B) NY1DD mice, as compared to appropriate strain and age-matched mice demonstrate elevated levels of collagen, as assessed by morphometric analysis of picrosirius red staining of lung tissue. N = six mice in each group. * p<0.05.