Table 3.

Data analysis of MADIT

	ICD (95% CI)	Conventional (95% CI)	Difference (95% CI)
Effectiveness*	3.45 yrs (3.26, 3.65)	2.65 yrs (2.34, 2.96)	0.80 yr (0.43, 1.17)
Cost (simple-weighted)*	$110109 (96526, 123692)	$70044 (51879, 88209)	$40065 (17383, 62747)
Cost (improved)*	$99548 (88786, 110,310)	$72754 (56023, 89485)	$26794 (6901, 46687)
ACER (simple-weighted)	$31883/yr	$26408/yr	$5475/yr
Fieller-normal	(27801, 36121)	(19290, 34198)	(−3061, 14011)+
Taylor-normal	(27730, 36036)	(19014, 33803)	(−2773, 13723)
Bootstrap-percentile	(27962, 36140)	(19992, 35088)	(−4030, 13788)
Bootstrap-normal	(27716, 36050)	(18801, 34015)	(−3289, 14191)
ACER (improved)	$28825/yr	$27430/yr	$1395/yr
Fieller-normal	(25603, 32173)	(20799, 34746)	(−6313, 9140)+
Taylor-normal	(25546, 32104)	(20513, 34346)	(−6259, 9049)
Bootstrap-percentile	(25568, 32099)	(20753, 36503)	(−7693, 8856)
Bootstrap-normal	(25587, 32063)	(19723, 35137)	(−7043, 9833)

^*for cost and effectiveness and their differences, normal-based formulae were used for CI.

⁺for CIs for the difference of the ACERs using Fieller’s method, we used the approximate relationship of standard error = (length of the CI)/(2*1.96).

For bootstrap methods, B=1000 replicates were generated.