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Panel A. Fentanyl and midazolam plasma time-concentration profiles were elevated under hypothermic conditions. Panel B. Hypothermia results in a modest decrease in the systemic clearances of both fentanyl (61.5±11.5 to 48.9±8.95 mL/min/kg) and midazolam (89.2±12.5 to 73.6±12.1 mL/min/kg) after CA. *Statistically significant effect (p < 0.05).
