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Fentanyl and midazolam brain to plasma concentration ratios. A nonsignificant trend towards decreased brain penetration during hypothermia was observed for fentanyl (1.39±0.444 to 1.06±0.330; p=0.08), but was less evident for midazolam (1.89±0.792 to 1.61±0.375; p=0.53).
