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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Jan 3;1825(2):186–196. doi: 10.1016/j.bbcan.2011.12.003

Figure 1. The multi-tier regulation of prostate cancer transcriptome.

Figure 1

The transcriptome of a cell includes the expression of thousands of genes/mRNA, hundreds of miRNAs, as well as an ever-growing number of ncRNAs. The expression of genes are tightly regulated by multiple mechanisms including small RNAs, transcription factors, DNA and histone modifications, as well as high-order chromatin structures including nucleosome positioning and DNA looping.