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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Nat Chem Biol. 2012 Mar 11;8(4):331–333. doi: 10.1038/nchembio.912

Figure 1.

Figure 1

Biosynthesis of (6’S,10’S)-7’,8’-dehydrozearalenol (DHZ, 1) by Hpm8 and Hpm3 from Hypomyces subiculosus. In Hpm8, ψMT represents the pseudo C-methyltransferase domain and ψKR denotes the structural KR, as designated in the mammalian FAS25. The biosynthesis of the highly-reduced acyl chain of 1 by Hpm8 is displayed in detail. The two chiral centers C6’ and C10’ are generated at diketide and tetraketide stages. The stereochemistry of the stereogenic centers in 1 can be assigned as d-S-OH-C6’ and l-S-OH-C10’.