Table 2.
Charge movement | Intracellular Ca2+ | |||||
---|---|---|---|---|---|---|
Mice | Qmax, μC/μF | V1/2Q, mV | K | ΔF/Fmax | V1/2F, mV | K |
3-M WT (n = 15–17)* |
30.5 ± 3.4 | 7.6 ± 0.92 | 14.2 ± 1.8 | 0.61 ± 0.08 | 12.9 ± 0.19 | 15.4 ± 1.8 |
3-M JP45KO (n = 16–20)* |
17.8 ± 2.6# | 6.4 ± 0.75 | 12.0 ± 1.5 | 0.39± 0.06# | 13.0 ± 0.15 | 16.3 ± 1.9 |
12-M JP45KO (n = 10) |
24.4 ± 0.8 | 5.6 ± 1.7 | 16 ± 1.2 | 0.43 ± 0.03 | 7.5 ± 0.51 | 11.9 ± 0.44 |
12-M WT (n = 11) | 31.2 ±0.5# | 1.1 ± 1.8 | 13.6 ± 1.6 | 0.54 ± 0.06 | 15.7 ± 0.9 | 11.3 ± 0.75 |
18-M JP45KO ( n = 12) |
24.9 ± 0.6 | 5.9 ± 1.1 | 14.7 ± 0.8 | 0.42 ± 0.05 | 6.9 ± 0.9 | 12.3 ± 0.74 |
18-M WT (n = 14) | 22.4 ± 0.5 | 5.1 ± 1.3 | 8.6 ± 0.8 | 0.44 ± 0.07 | 7.6 ± 1.2 | 9.8 ± 1.0 |
Values are mean ± SEM. “n” indicates the number of fibers.
P < 0.05 statistically significant difference between WT and JP45KO mice.
Data from ref. (Delbono et al., 2007).