. Author manuscript; available in PMC: 2013 Mar 1.

Published in final edited form as: J Vet Cardiol. 2012 Feb 20;14(1):19–29. doi: 10.1016/j.jvc.2012.01.006

Table 2.

Genes within loci linked to body size in the dog and their possible associations to heart development.

Chr	Mb^a	Gene	Size GWAS^b	Cardiac Involvement	L.G.^c Cardiac Involvement	Ref.^d
4	42.3	STC2	3		NKX2–5 – valve formation defects	41
7	46.7	SMAD2	2,3	Valve remodeling and development		30
10	11.4	HMGA2	2,3	Cardiogenesis		28
15	37	SOCS2	2	Interacts with IGF1R, controls heart growth		62
15	44.2	IGF1	1,2,3	Controls heart growth		63
34	21.4	IGF2BP2	2		SENP2 – embryonic heart defect	64
37	29.7	OBSL1	1		CHPF - valve development	65

^A)

Positions in Mb on CanFam2 build.

^B)

References for the canine body size GWAS studies: 1=Chase et al. 200222, 2=Jones et al. 200827, 3=Boyko et al. 201032.

^C)

L.G. = linked gene.

^D)

One representative reference relating each gene to heart development or disease.