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. Author manuscript; available in PMC: 2013 Apr 15.
Published in final edited form as: Eur J Pharmacol. 2012 Feb 20;681(1-3):80–87. doi: 10.1016/j.ejphar.2012.02.018

Fig. 7. Proposed involvement of MRP4 and CFTR in β1-adrenergic stimulation.

Fig. 7

A. 10−8 M isoproterenol stimulation. B. 10−5 M isoproterenol stimulation. C. 10−8 M isoproterenol stimulation in the presence of MRP4 inhibition by MK571. D. 10−8 M isoproterenol stimulation in the presence of PDE4 inhibition by rolipram. Additional abbreviations: β1-AR, β1-adrenoceptors; AC, adenylyl cyclase; NBD, nucleotide binding domain of CFTR; R, regulatory domain of CFTR; SR, sarcoplasmic reticulum; CaCC, Ca2+-activated Cl− channels.