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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Mol Cancer Res. 2012 Jan 12;10(3):282–292. doi: 10.1158/1541-7786.MCR-11-0404

Figure 1. Disseminated PCa alters BMP expression in HSC/HPCs.

Figure 1

(A) Experimental outline. HSCs (CD150+ Lin− CD48− CD41− Sca-1+ cKit+ (SLAM HSCs) or Lin− CD48− CD41− Sca-1+ cKit+ (LSK HSCs)/HPCs (Lin− CD48− CD41−Sca1+) from tumor bearing animals were isolated. Total RNA was extracted and subjected to qRT-PCR for BMP-2 and BMP-6. Relative expression of mRNA was calculated for (B) BMP-2 and (C) BMP-6 and normalized to GAPDH. Data represent mean ± SD performed in triplicate in 3 independent experiments. Level of significance (p<0.001 and p<0.01) were calculated compared to the surgical control treated group.