Scheme 4.
Conditions: (a) H2, Pd/C, EtOH, 3h; (b)Ac2O, DIEA, THF, 24h, rt; (c) 3-methyl-1H-pyrazole-4-carboxylic acid, EDC, Et3N, HOBt, CH2Cl2; (d) nicotinaldehyde, NaBH(OAc)3, THF/DMF, 48 h.
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