Table 2. Expression change of senescence-associated miRNAs in IMR90 cells treated with DEM or etoposide.
|
DEM |
Etoposide |
|||||
|---|---|---|---|---|---|---|
| miRNA | Fold variationa | S.D. | P-value | Fold variationa | S.D. | P-value |
| miR-486-5p | 1.55 | 0.118 | 0.0018 | 3.22 | 0.07 | <0.0001 |
| miR-210 | 1.69 | 0.12 | <0.0001 | 1.5 | 0.2 | 0.0001 |
| miR-30e-5p | 3.25 | 0.57 | 0.0008 | 1.82 | 0.03 | <0.0001 |
| miR-376a* | 2.87 | 0.89 | <0.0001 | 1.7 | 0.27 | 0.0023 |
| miR-126* | 2.35 | 0.28 | 0.0004 | 2.05 | 0.15 | 0.0001 |
| miR-494 | 2.14 | 0.2 | 0.0011 | 0.93 | 0.04 | 0.2652 |
| miR-379 | 1.52 | 0.06 | 0.0001 | 1.39 | 0.08 | 0.0070 |
| miR-654 | 2.29 | 0.53 | 0.0046 | 1.16 | 0.8 | 0.5177 |
| miR-542-5p | 1.128 | 0.14 | 0.5818 | 1.22 | 0.04 | 0.0224 |
| miR-23b | 1.94 | 0.12 | 0.0002 | 1.42 | 0.18 | 0.0105 |
| miR-134 | 1.52 | 0.12 | 0.0032 | 1.67 | 0.002 | <0.0001 |
| miR-369-3p | 1.44 | 0.13 | 0.0036 | 1.61 | 0.03 | <0.0001 |
| miR-656 | 1.26 | 0.06 | 0.0181 | 1.21 | 0.04 | 0.0137 |
| miR-485-5p | 2.33 | 0.08 | 0.0001 | 1.36 | 0.11 | 0.0420 |
| miR-20a | 0.419 | 0.002 | <0.0001 | 0.29 | 0.03 | <0.0001 |
| miR-155 | 0.2 | 0.002 | <0.0001 | 0.32 | 0.014 | <0.0001 |
| miR-17-5p | 0.51 | 0.01 | <0.0001 | 0.43 | 0.04 | 0.0086 |
| miR-199b-5p | 0.55 | 0.06 | 0.069 | 0.37 | 0.02 | <0.0001 |
| miR-15b | 0.33 | 0.016 | <0.0001 | 0.33 | 0.02 | 0.0013 |
| miR-92 | 0.43 | 0.08 | 0.0018 | 0.37 | 0.01 | 0.0003 |
| miR-296-5p | 0.72 | 0.005 | 0.0007 | 0.7 | 0.02 | 0.0059 |
| miR-19b | 0.39 | 0.14 | 0.0125 | 0.33 | 0.04 | 0.0002 |
| miR-93 | 0.45 | 0.02 | 0.0006 | 0.46 | 0.06 | 0.0009 |
| miR-106b | 0.84 | 0.01 | <0.0001 | 0.65 | 0.07 | 0.0396 |
With respect to untreated cells.